About: Ligand unbound FtsZ (Grey), GDP bound FtsZ (Bue), GTP bound FtsZ (Bue), (S)rhodomyrtone bound FtsZ

3VOA

Effects of rhodomyrtone on Gram-positive bacterial tubulin homologue FtsZ

Information

Details.

Scientist
Thanyada Rungrotmongkol
Protein
FtsZ
Ligand
rhodomyrtone
Simulation Duration
150 ns
InChIKey
QNSNMYHREQPTRX-UHFFFAOYSA-M
SMILES
CC1CCN(CC1)C2=CC(=[N+](C3=CC=CC=C32)C)/C=C/C4=CC=C(C=C4)N(C)C.[I-]
Molecular Formula
C26H32IN3
Protein Details
During cell division, FtsZ is the first protein to move to the division site, and is essential for recruiting other proteins that produce a new cell wall (septum) between the dividing cells.
Ligand Details
Rhodomyrtone, a natural antimicrobial compound, displays potent activity against many Gram-positive pathogenic bacteria, comparable to last-defence antibiotics including vancomycin and daptomycin.
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