About: The RMSD of the NPxxY motif between the active and inactive structures of the M2 receptor (3.6 Å) is also plotted in a dashed red line. Red rectangles highlight activation events of the M3 receptor .

4DA J

Allosteric Effects of Sodium Ion Binding on Activation of the M3 Muscarinic G-Protein-Coupled Receptor

Download

Information

Details.

Scientist
J.Andrew MC Cammon
Protein
M3 muscarinic
Ligand
NPxxY
Simulation Duration
600ns
InChIKey
RAOULLCLLOGTDA-UHFFFAOYSA-N
SMILES
CC1=CC=C(C=C1)C2=CSC3=C2C(=NC=N3)SCCC(=O)O
Molecular Formula
C16H14N2O2S2
Protein Details
G-protein-coupled receptors (GPCRs) are important membrane proteins that mediate cellular signaling and represent primary targets for about one-third of currently marketed drugs
Ligand Details
Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
Attachments